The purpose of SIK1 in tumorigenesis. SIK1 is a tumor suppressor gene, which plays a vital regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may endorse cancer mobile … Read More